Proof of Concept Video for Retinitis Pigmentosa
This video demonstrates the ability of Eos-013 to restore functional sight to mice that are genetically blind due to a naturally occurring disease similar to retinitis pigmentosa
in humans. These mice have lost the ability to see because their photoreceptors, the cells in their eyes that capture light, have died. However, the rest of the eye remains intact. Eos-013 restores functional vision by giving bipolar cells the ability to capture light. This is accomplished with a therapy that delivers the gene for a light activated protein to the bipolar cells of the retina, allowing these cells to both capture light and perform their normal tasks of processing and transmitting optical signals to the optic nerve. Eos-013 uses an AAV vector system
and a promotor specific to bipolar cells.